ReproGenomics Mutants
Low/Abnormal Spermatogonia
| Gene | Family ID # | Chromosome | Chromosome Region* (Ensembl Build 33) |
Status | Post Date | |
| Flanking Markers | Base Pair | |||||
| repro19 | G1-472-18 | Chr 16 | D16Mit165 to D16Mit103 | 12732404-30793475 | Cryopreserved | 1/18/05 |
| Male Phenotype |
In vitro clinic: Low testis weight, low seminal vesicle weight, low epididymal sperm concentration, abnormally shaped sperm heads with missing or short sperm tails, variable motility, very low IVF success. Histology evaluation: Abnormal spermatogenesis (see 1-3) with low/abnormal spermatogonia and spermatocytes. Abnormal spermiogenesis with abnormal spermatid heads (see 2), low number of spermatids in testis lumen (see 3). Hormone analysis: High levels of luteinizing hormone and testosterone. |
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| repro22 | G1-453-4 | Chr 4 | D4Mit54 to D4Mit42 | 136771799-150062357 | Cryopreserved | 1/4/05 |
| Male Phenotype |
In vitro clinic: Very low testis weight, no epididymal sperm recovered. Histology evaluation: Germ cell depletion, spermatogonia present but no later spermatogenic stages (see 1-2). |
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| Female Phenotype |
In vitro clinic: No oocytes recovered. |
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