ReproGenomics Mutants
Low/Abnormal Spermatocytes
| Gene | Family ID # | Chromosome | Chromosome Region* (Ensembl Build 33) |
Status | Post Date | |
| Flanking Markers | Base Pair | |||||
| repro14 | G1-449-31 | Chr 5 | D5Mit338 to D5Mit25 | 107690857-112994570 | Cloning in progress, ReproGenomics |
5/14/07 |
| Male Phenotype |
In vitro clinic: Very low testis weight, no epididymal sperm recovered. Histology evaluation: Arrest of spermatogenesis predominantly at pachytene stage of meiotic prophase or meiotic division stage (see 1), some germ cells appear apoptotic (see 2). |
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| Female Phenotype |
In vitro clinic: No oocytes recovered. Histology evaluation: Tiny ovaries with no growing oocytes or follicles (see 3). |
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| repro7 | G1-419-29 | Chr 17 | D17Mit113 to D17Mit197 | 10619362-18003802 | Cloning in progress, ReproGenomics |
5/14/07 |
| Male Phenotype |
In vitro clinic: Very low testis weight, no epididymal sperm recovered. Histology evaluation: Arrest of spermatogenesis during mid-pachytene stage of meiotic prophase (see 1), some seminiferous tubules are greatly depleted of germ cells (see 2). |
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| Female Phenotype |
In vitro clinic: No oocytes recovered. Histology evaluation: Tiny ovaries with few growing oocytes (see 3). |
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| repro4 | G1-397-34 | Chr 1 | D1Mit303 to D1Mit46 | 63200615-75863523 | Cloning in progress, ReproGenomics |
5/14/07 |
| Male Phenotype |
In vitro clinic: Very low testis weight, no epididymal sperm recovered. Histology evaluation: Arrest of spermatogenesis during late pachytene stage of meiotic prophase (see 1), some germ cells appear apoptotic (see 2). |
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| repro46 | G1-565-6 | Chr 9 | D9Mit96 to D9Mit301 | 50826065-56699792 | Limited shelf availability |
5/14/07 |
| Male Phenotype |
In vitro clinic: Very low testis weight, low seminal vesicle weight, no epididymal sperm recovered. Histology evaluation: Arrest of spermatogenesis during late pachytene stage of meiotic prophase (see 1), some seminiferous tubules have only spermatogonia and Sertoli cells present (see 1), some germ cells appear apoptotic (see 2). |
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| Female Phenotype |
In vitro clinic: No oocytes recovered. Histology evaluation: Tiny ovaries with some follicle activity (see 3), hemorrhagic cysts present in some ovaries (see 4). |
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| repro36 | G1-569-2 | Chr 9 | D9Mit71 to D9Mit103 | 50248563-60611959 | Limited shelf availability |
5/14/07 |
| Male Phenotype |
In vitro clinic: Very low testis weight, low seminal vesicle weight, no epididymal sperm recovered. Histology evaluation: Arrest of spermatogenesis during pachytene stage of meiotic prophase, some tubules are greatly depleted of germ cells (see 1). |
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| Female Phenotype |
In vitro clinic: No oocytes recovered. Histology evaluation: Tiny ovaries with no growing oocytes or follicles (see 2). |
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| repro57 | G1-586-2 | Chr 5 | D5Mit312 to D5Mit68 | 95409878-118958939 | Cryopreserved | 5/14/07 |
| Male Phenotype |
In vitro clinic: Very low testis weight, low seminal vesicle weight, no epididymal sperm recovered. Histology evaluation: Arrest of spermatogenesis during late pachytene stage of meiotic prophase (see 1), some germ cells appear apoptotic (see 2). |
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| repro34 | G1-536-1 | Chr 5 | D5Mit138 to D5Mit372 | 124262463-131316975 | Cryopreserved | 1/20/06 |
| Male Phenotype |
In vitro clinic: Very low testis weight, low seminal vesicle weight, no epididymal sperm recovered. Histology evaluation: Abnormal spermiogenesis with accumulation of meiotic division-phase spermatocytes and degenerating round spermatids present in multinucleated cell bodies (see 1). |
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| repro23 | G1-476-14 | Chr 7 |
D7Mit266 to D7Mit247 | 23698649-32307081 | Cryopreserved | 1/18/05 |
| Male Phenotype |
In vitro clinic: Very low testis weight, no epididymal sperm recovered. |
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| repro19 | G1-472-18 | Chr 16 | D16Mit165 to D16Mit103 | 12732404-30793475 | Cryopreserved | 1/18/05 |
| Male Phenotype |
In vitro clinic: Low testis weight, low seminal vesicle weight, low epididymal sperm concentration, abnormally shaped sperm heads with missing or short sperm tails, variable motility, very low IVF success. Histology evaluation: Abnormal spermatogenesis (see 1-3) with low/abnormal spermatogonia and spermatocytes. Abnormal spermiogenesis with abnormal spermatid heads (see 2), low number of spermatids in testis lumen (see 3). Hormone analysis: High levels of luteinizing hormone and testosterone. |
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| repro8 | G1-419-52 | Chr 4 | D4Mit204 to D4Mit42 | 132388267-150062357 | Cloning in progress, ReproGenomics |
8/20/04 |
| Male Phenotype |
In vitro clinic: Very low testis weight, no epididymal sperm recovered. Histology evaluation: Low/abnormal spermatocytes with arrest of spermatogenesis at early to mid-meiotic prophase (see 1-3). |
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