ReproGenomics Mutants
Female Mutants
| Gene | Family ID # | Chromosome | Chromosome Region* (Ensembl Build 33) |
Status | Post Date | |
| Flanking Markers | Base Pair | |||||
| repro14 | G1-449-31 | Chr 5 | D5Mit338 to D5Mit25 | 107690857-112994570 | Cloning in progress, ReproGenomics |
5/14/07 |
| Female Phenotype |
In vitro clinic: No oocytes recovered. Histology evaluation: Tiny ovaries with no growing oocytes or follicles (see 3). |
|||||
| Male Phenotype |
In vitro clinic: Very low testis weight, no epididymal sperm recovered. Histology evaluation: Arrest of spermatogenesis predominantly at pachytene stage of meiotic prophase or meiotic division stage (see 1), some germ cells appear apoptotic (see 2). |
|||||
| repro7 | G1-419-29 | Chr 17 | D17Mit113 to D17Mit197 | 10619362-18003802 | Cloning in progress, ReproGenomics |
5/14/07 |
| Female Phenotype |
In vitro clinic: No oocytes recovered. Histology evaluation: Tiny ovaries with few growing oocytes (see 3). |
|||||
| Male Phenotype |
In vitro clinic: Very low testis weight, no epididymal sperm recovered. Histology evaluation: Arrest of spermatogenesis during mid-pachytene stage of meiotic prophase (see 1), some seminiferous tubules are greatly depleted of germ cells (see 2). |
|||||
| repro46 | G1-565-6 | Chr 9 | D9Mit96 to D9Mit301 | 50826065-56699792 | Limited shelf availability |
5/14/07 |
| Female Phenotype |
In vitro clinic: No oocytes recovered. Histology evaluation: Tiny ovaries with some follicle activity (see 3), hemorrhagic cysts present in some ovaries (see 4). |
|||||
| Male Phenotype |
In vitro clinic: Very low testis weight, low seminal vesicle weight, no epididymal sperm recovered. Histology evaluation: Arrest of spermatogenesis during late pachytene stage of meiotic prophase (see 1), some seminiferous tubules have only spermatogonia and Sertoli cells present (see 1), some germ cells appear apoptotic (see 2). |
|||||
| repro36 | G1-569-2 | Chr 9 | D9Mit71 to D9Mit103 | 50248563-60611959 | Limited shelf availability |
5/14/07 |
| Female Phenotype |
In vitro clinic: No oocytes recovered. Histology evaluation: Tiny ovaries with no growing oocytes or follicles (see 2). |
|||||
| Male Phenotype |
In vitro clinic: Very low testis weight, low seminal vesicle weight, no epididymal sperm recovered. Histology evaluation: Arrest of spermatogenesis during pachytene stage of meiotic prophase, some tubules are greatly depleted of germ cells (see 1). |
|||||
| repro22 | G1-453-4 | Chr 4 | D4Mit54 to D4Mit42 | 136771799-150062357 | Cryopreserved | 1/4/05 |
| Female Phenotype |
In vitro clinic: No oocytes recovered. |
|||||
| Male Phenotype |
In vitro clinic: Very low testis weight, no epididymal sperm recovered. Histology evaluation: Germ cell depletion, spermatogonia present but no later spermatogenic stages (see 1-2). |
|||||
| repro5 | G1-403-16 | Chr 16 | D16Mit86 to D16Mit106 | 92299378-97314451 | Limited shelf availability |
10/23/03 |
| Female Phenotype |
In vitro clinic: Oocytes commonly contain vacuoles; oocytes have low developmental competence to 2-cell and blastocyst stages. Histology evaluation: Growing and degenerating oocytes commonly contain vacuoles (see 3-4) |
|||||
| Male Phenotype |
In vitro clinic: Low epididymal sperm concentration, low sperm motility, abnormal sperm head morphology, no IVF success. Histology evaluation: Abnormal spermiogenesis, few spermatids (see1), abnormal sperm heads (see 2). |
|||||
